Effect of Induced Ventricular Fibrillation and Shock Delivery on Brain Natriuretic Peptide Measured Serially Following a Predischarge ICD Test

OBJECTIVES Brain natriuretic peptide (BNP) was a marker for heart failure and cardiac wall tension. We analysed the trend of BNP after predischarge testing in order to get non-invasive details about the cardiac stress during predischarge testing. METHODS 4-5 days after ICD implant we measured BNP, myoglobin, cardiac troponin I and creatine kinase in 20 patients before and 1, 5, 10, 20, 40, 60, 80, 100, 120 minutes and at the next day after predischarge testing. We evaluated actual values and percentage alterations of BNP. RESULTS BNP significantly increased with a maximum after 5 minutes (804.0 +/- 803.4 vs. 475.7 +/- 629.5 pg/ml, P < 0.0001) and in terms of the percentage values (100 vs. 199.4 +/- 61.4 %, P < 0.0001) compared with baseline BNP. BNP decreased after that with the last significantly increased BNP value after 20 minutes (540.2 +/- 604.9 vs. 475.7 +/- 629.5 pg/ml, P = 0.017). We excluded a cardiac necrosis during predischarge testing because of similar values of myoglobin, cardiac troponin I and creatine kinase during the 2-hour follow-up. CONCLUSION Our data showed a great increase with a doubling of BNP after 5 minutes as a result of induced ventricular fibrillation during predischarge test. This increase was not generated by myocardial necrosis but rather caused by an acute cardiac failure as a consequence of induced ventricular fibrillation in predischarge testing.